Try this Slow Cooker Boeuf Bourguignon recipe.
Unlike a rapid-boiling beef stew that tightens muscle fibers into rubbery bullets, classical bourguignon relies on a protracted enzymatic breakdown of collagen. Tough cuts like chuck or stew meat contain dense connective tissue networks consisting of triple-helix protein chains. Exposing these tough cuts to a sustained thermal environment between 180°F and 200°F for eight to ten hours causes insoluble collagen to melt into soluble gelatin, transforming what would otherwise be shoe leather into a luxurious, mouth-coating unctuosity that thickens the surrounding braising liquid.
Coating the drained, marinated beef in all-purpose flour prior to slow cooking serves a dual chemical purpose that alters the final sauce consistency. As the starches hydrate and gelatinize during the long thermal phase, they trap suspended fat droplets, preventing the red wine reduction from separating into an oily film. Tossing the meat directly with the dry flour rather than stirring it into the liquid avoids lump formation, because individual starch granules hydrate independently when dusted directly onto a damp surface. When substituting dry red wine with a non-alcoholic alternative like beef stock spiked with two tablespoons of red wine vinegar, expect a thinner final sauce because organic acids and tannins present in actual wine assist in protein denaturation.