Try this Slow Cooker Beef Stew recipe.
Twelve hours of continuous heat demands a cut of meat that contains sufficient collagen to withstand breakdown without drying out completely. Chuck roast cut into one-inch cubes works best here because the connective tissue dissolves into gelatin, yielding a rich mouthfeel rather than a chalky texture. Direct incorporation of raw flour into the liquid inside the slow cooker can sometimes produce lumps if not thoroughly distributed, so coating the beef cubes directly with the dry mixture before adding liquids ensures proper starch dispersion.